| Identification | Back Directory | [Name]
Benzamide, N-[4-[(5,6-dimethoxy-3-pyridinyl)carbonyl]-4,5,6,7-tetrahydro-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridin-7-yl]-2-(trifluoromethoxy)- | [CAS]
2035010-37-6 | [Synonyms]
Benzamide, N-[4-[(5,6-dimethoxy-3-pyridinyl)carbonyl]-4,5,6,7-tetrahydro-1-(1-methylethyl)-1H-pyrazolo[4,3-b]pyridin-7-yl]-2-(trifluoromethoxy)- | [Molecular Formula]
C25H26F3N5O5 | [MOL File]
2035010-37-6.mol | [Molecular Weight]
533.5 |
| Hazard Information | Back Directory | [Uses]
ALT-007 is an orally effective serine palmitoyltransferase (SPT) inhibitor. SPT is the rate-limiting enzyme for the de novo synthesis of ceramide. In a mouse model of age-related sarcopenia, ALT-007 can effectively restore the muscle mass and function impaired by aging. ALT-007 may enhance protein homeostasis in Caenorhabditis elegans and mouse models of aging and age-related diseases and play the role of a ceramide inhibitor[1]. | [References]
[1] Poisson J, et al. Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia. ACS Pharmacol Transl Sci. 2024 Dec 29;8(1):203-215. DOI:10.1021/acsptsci.4c00587 |
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| Company Name: |
ChemOrigin Pharm
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15026428026 19002516454 |
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chemorigin.com/ |
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