| Identification | More | [Name]
4-(2-Aminoethyl)morpholine | [CAS]
2038-03-1 | [Synonyms]
2-(4-MORPHOLINO)ETHYLAMINE
2-MORPHOLIN-4-YL-ETHYLAMINE
2-MORPHOLINOETHYLAMINE
4-(2-AMINOETHYL)MORPHOLINE
4-MORPHOLINEETHANAMINE
LABOTEST-BB LT02100621
N-(2-AMINOETHYL)MORPHOLINE
N-AMINOETHYL MORPHOLINE
RARECHEM AL BW 0412
1-Amino-2-morpholinoethane
2-(4-Morpholinyl)ethanamine
2-(4-Morpholinyl)ethylamine
4-(2-aminoethyl)-morpholin
beta-Aminoaethyl-morpholin
beta-Morpholinoethylamine
Morpholine, 4-(2-aminoethyl)-
Morpholinoethylamine
N-(beta-Aminoethyl)morpholine
N-2-Aminoethylmorfolin
4-Morpholineethaneamine | [EINECS(EC#)]
218-011-6 | [Molecular Formula]
C6H14N2O | [MDL Number]
MFCD00006182 | [Molecular Weight]
130.19 | [MOL File]
2038-03-1.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to pale yellow liq. after melting | [Melting point ]
24 °C
| [Boiling point ]
205 °C(lit.)
| [density ]
0.992 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.476(lit.)
| [Fp ]
347 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Chloroform, Methanol | [form ]
Liquid After Melting | [pka]
pK1: 4.06(+2);pK2: 9.15(+1) (25°C) | [color ]
Clear colorless to pale yellow | [Water Solubility ]
soluble | [Sensitive ]
Air Sensitive | [BRN ]
104378 | [Stability:]
Air Sensitive | [InChIKey]
RWIVICVCHVMHMU-UHFFFAOYSA-N | [CAS DataBase Reference]
2038-03-1(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Morpholineethanamine(2038-03-1) | [EPA Substance Registry System]
2038-03-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,T | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R24:Toxic in contact with skin.
R40:Limited evidence of a carcinogenic effect.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S22:Do not breathe dust . | [RIDADR ]
UN 2735 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
QD7350000
| [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29349990 | [Toxicity]
guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944. |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to pale yellow liq. after melting | [Uses]
4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II). | [Definition]
ChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 34, p. 1805, 1991 DOI: 10.1021/jm00110a008 | [Synthesis]
General procedure for the synthesis of N-(2-aminoethyl)morpholine from 2-morpholinoacetonitrile: LiAlH4 (3.19 g, 84 mmol) was added to anhydrous THF (35 mL) in a single step under ice bath conditions. The reaction mixture was stirred at 0 °C for 20 min, followed by the dropwise addition of 2-morpholino-substituted acetonitrile (3.50 g, 28 mmol) to a solution of anhydrous THF (10 mL). After the dropwise addition, the reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to 0 °C and water (20 mL) was slowly added to quench the reaction. After filtration to remove insoluble material, the filtrate was concentrated in vacuum to give N-(2-aminoethyl)morpholine as a yellow oil (2.62 g, 72% yield). | [References]
[1] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00363
[2] Patent: US2015/87639, 2015, A1. Location in patent: Paragraph 0650
[3] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 146
[4] Bulletin de la Societe Chimique de France, 1955, p. 218
[5] Patent: CN108658937, 2018, A. Location in patent: Paragraph 0151; 0152; 0231; 0232 |
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