| Identification | Back Directory | [Name]
SB 223412-A | [CAS]
204519-66-4 | [Synonyms]
SB 223412-A
SB223412 hydrochloride
SB-223412 hydrochloride
SB 223412 hydrochloride
Talnetant (hydrochloride)
SB-223412 HYDROCHLORIDE; SB223412 HYDROCHLORIDE; SB 223412 HYDROCHLORIDE; SB 223412-A | [Molecular Formula]
C25H23ClN2O2 | [MDL Number]
MFCD26960955 | [MOL File]
204519-66-4.mol | [Molecular Weight]
418.92 |
| Hazard Information | Back Directory | [Uses]
Treatment of symptoms associated with bladder dysfunction (SABD), including urinary urgency, frequency and/or urinary incontinence (NK-3 receptor antagonist). | [in vivo]
Talnetant (SB 223412) hydrochloride (0.5-2 mg/kg iv, 2min pretreatment) can inhibit the miosis induced by senktide (25μg, iv) in a dose-dependent manner with an ED50 of 0.44mg/kg in conscious rabbits[1].
Talnetant (SB 223412) hydrochloride (i.p., 1-100 mg/kg, 1 h) can significantly attenuate senktide-induced "wet dog wagging" behavior in a dose-dependent manner, significantly increase extracellular dopamine and norepinephrine in the medial prefrontal cortex and reduce haloperidol-induced increases in dopamine levels in the vomeronasal nucleus of freely moving guinea pigs[3].
| Animal Model: | Male Dunkin-Hartley guinea pig[3] | | Dosage: | 1, 3, 10, 30 or 100?mg/kg | | Administration: | Intraperitoneal injection; 1 h | | Result: | Showed a significant attenuation of wet dog shake (WDS) behavior from 31.1 to 16.7 at 30 mg/kg.
Significantly increased extracellular DA levels to 238% and NE levels to 227.1%, without affecting 5-HT levels.
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| [IC 50]
NK3 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|