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2050232-20-5

2050232-20-5 Structure

2050232-20-5 Structure
IdentificationBack Directory
[Name]

Belantamab Mafodotin
[CAS]

2050232-20-5
[Synonyms]

Belantamab Mafodotin
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity[1][2].
[in vivo]

Belantamab mafodotin signifcantly improves survival compared to vehicle in mice harbouring OPM2 tumours[2].

Animal Model:Mice harbouring OPM2 tumours[2]
Dosage:4 mg/kg
Administration:IP, twice weekly for 4 doses
Result:Signifcantly improves survival compared to vehicle.
[References]

[1] Hulin C, et al. Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study. Lancet Oncol. 2020 Feb;21(2):207-221. DOI:10.1016/S1470-2045(19)30788-0
[2] Markham A. Belantamab Mafodotin: First Approval. Drugs. 2020 Oct;80(15):1607-1613. DOI:10.1007/s40265-020-01404-x
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