| Identification | Back Directory | [Name]
Propargyl-PEG10-t-butyl ester | [CAS]
2055022-22-3 | [Synonyms]
2055022-22-3
CAS_2055022-22-3
Propargyl-PEG10-Boc
Propargyl-PEG10-COOtBu
Propargyl-PEG10-t-Bu Ester
Propargyl-PEG9-CH2CH2COOtBu
Propargyl-PEG10-t-butyl ester
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-ynoic acid, 1,1-dimethylethyl ester | [Molecular Formula]
C28H52O12 | [MDL Number]
MFCD28976692 | [MOL File]
2055022-22-3.mol | [Molecular Weight]
580.71 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG10-t-butyl ester is a crosslinking reagent that can react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The carboxyl group can be deprotected under acidic conditions. | [Uses]
Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG10-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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