| Identification | Back Directory | [Name]
MOZ-IN-3 | [CAS]
2055397-18-5 | [Synonyms]
MOZ-IN-3
KAT6B inhibitor
KAT6A inhibitor
MOZ-IN-3/WM-8014
WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR
[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide | [Molecular Formula]
C20H17FN2O3S | [MOL File]
2055397-18-5.mol | [Molecular Weight]
384.42 |
| Chemical Properties | Back Directory | [density ]
1.307±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml | [form ]
A crystalline solid | [pka]
7.15±0.25(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2. | [Uses]
MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B. | [IC 50]
MOZ/MORF | [storage]
Store at -20°C |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|