| Identification | Back Directory | [Name]
CB 30865 | [CAS]
206275-15-2 | [Synonyms]
ZM242421
CB 30865
ZM 242421
ZM-242421
4-[[(7-Bromo-1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-N-(3-pyridinylmethyl)benzamide
Benzamide, 4-[[(7-bromo-3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl)- | [Molecular Formula]
C26H22BrN5O2 | [MDL Number]
MFCD00947652 | [MOL File]
206275-15-2.mol | [Molecular Weight]
516.39 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [solubility ]
DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
14.31±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range)[1][2]. CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664. DOI:10.1016/j.chembiol.2010.05.008
[2] Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. DOI:10.1002/(sici)1097-0320(19980901)33:13.0.co;2-9 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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