| Identification | Back Directory | [Name]
Pasiniazid | [CAS]
2066-89-9 | [Synonyms]
Dipasic
Pashain
Fintozid
Nidrapas
Pascidaber
PASINIAZID
Paraniazide
PAS(AMINOSALICYLIC)ISONIAZIDE
4-azanyl-2-hydroxy-benzoic acid
PASINIAZIDISONIAZID AMINOSALICYLATE UV
isonicotinicacidhydrazidep-*aminosalicylate
isonicotinic acid hydrazide 4-aminosalicylate
4-AMINOSALICYLATE ISO-NICOTINIC ACID HYDRAZIDE
Hydrazideisonicotinic acid-p-aminosalicylic acid
ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT
4-AMINOSALICYLATEISO-NICOTINICACIDHYDRAZIDE(PASINIAZID) | [EINECS(EC#)]
218-183-2 | [Molecular Formula]
C13H14N4O4 | [MDL Number]
MFCD00079376 | [MOL File]
2066-89-9.mol | [Molecular Weight]
290.27 |
| Chemical Properties | Back Directory | [Melting point ]
142-144° | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Water | [form ]
neat | [color ]
Light yellow to khaki | [InChI]
InChI=1S/C7H7NO3.C6H7N3O/c8-4-1-2-5(7(10)11)6(9)3-4;7-9-6(10)5-1-3-8-4-2-5/h1-3,9H,8H2,(H,10,11);1-4H,7H2,(H,9,10) | [InChIKey]
RKPHTRVPGYGVQD-UHFFFAOYSA-N | [SMILES]
C1(C(=O)O)C=CC(N)=CC=1O.C1(C(=O)NN)=CC=NC=C1 |
| Hazard Information | Back Directory | [Uses]
antibacterial (tuberculostatic) | [Originator]
Pasinazid, Yick-Vic Chemicals | [Manufacturing Process]
10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).
Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative | [Therapeutic Function]
Antitubercular | [storage]
Store at -20°C, protect from light |
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AFINE CHEMICALS LIMITED
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+86-571-85134551 +86-18958018566 |
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www.afinechem.com/index.html |
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