| Identification | Back Directory | [Name]
Acid-PEG2-t-butyl ester | [CAS]
2086688-99-3 | [Synonyms]
COOH-PEG2-OtBu
Acid-PEG2-C2-Boc
t-butyl ester-PEG1-acid
Acid-PEG2-t-butyl ester
3-(2-(3-(tert-Butoxy)-3-oxopropoxy)ethoxy)propanoic acid
3-[2-(2-Carboxyethoxy)ethoxy]propanoic acid tert-butyl ester
Propanoic acid, 3-[2-(2-carboxyethoxy)ethoxy]-, 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C12H22O6 | [MDL Number]
MFCD30723272 | [MOL File]
2086688-99-3.mol | [Molecular Weight]
262.3 |
| Chemical Properties | Back Directory | [Boiling point ]
384.3±27.0 °C(Predicted) | [density ]
1.104±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF | [form ]
Liquid | [pka]
4.27±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C12H22O6/c1-12(2,3)18-11(15)5-7-17-9-8-16-6-4-10(13)14/h4-9H2,1-3H3,(H,13,14) | [InChIKey]
FVMOAKLTZMCDOV-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCC(O)=O |
| Hazard Information | Back Directory | [Description]
Acid-PEG2-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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