Chemical Properties | Back Directory | [solubility ]
Chloroform: Slightly Soluble: 0.1-1 mg/ml Methanol: Slightly Soluble: 0.1-1 mg/ml | [form ]
Oil | [color ]
White to light yellow |
Hazard Information | Back Directory | [Uses]
ZA3-Ep10?is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery. | [in vivo]
ZA3-Ep10 nanoparticle (LNP carrying Cy5-labeled mRNA, i.v.) produces protein mostly in the lungs (70%) of mice[3].
| [References]
[1] Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids. WO2017201076A1 [2] Melamed JR, Hajj KA, Chaudhary N, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery.?J Control Release. 2022;341:206-214. DOI:10.1016/j.jconrel.2021.11.022 [3] Melamed JR, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022 Jan;341:206-214. DOI:10.1016/j.jconrel.2021.11.022 [4] Miller JB, et al. Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063. DOI:10.1002/anie.201610209 [5] He S, et al. Zwitterionic materials for nucleic acid delivery and therapeutic applications. J Control Release. 2024 Jan;365:919-935. DOI:10.1016/j.jconrel.2023.12.017 |
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