ChemicalBook--->CAS DataBase List--->2090299-48-0

2090299-48-0

2090299-48-0 Structure

2090299-48-0 Structure
IdentificationBack Directory
[Name]

ZA3-Ep10
[CAS]

2090299-48-0
[Synonyms]

ZA3-Ep10
[Molecular Formula]

C66H138N6O9S
[MOL File]

2090299-48-0.mol
[Molecular Weight]

1191.92
Chemical PropertiesBack Directory
[solubility ]

Chloroform: Slightly Soluble: 0.1-1 mg/ml
Methanol: Slightly Soluble: 0.1-1 mg/ml
[form ]

Oil
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

ZA3-Ep10?is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.
[in vivo]

ZA3-Ep10 nanoparticle (LNP carrying Cy5-labeled mRNA, i.v.) produces protein mostly in the lungs (70%) of mice[3].

[References]

[1] Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids. WO2017201076A1
[2] Melamed JR, Hajj KA, Chaudhary N, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery.?J Control Release. 2022;341:206-214. DOI:10.1016/j.jconrel.2021.11.022
[3] Melamed JR, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022 Jan;341:206-214. DOI:10.1016/j.jconrel.2021.11.022
[4] Miller JB, et al. Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063. DOI:10.1002/anie.201610209
[5] He S, et al. Zwitterionic materials for nucleic acid delivery and therapeutic applications. J Control Release. 2024 Jan;365:919-935. DOI:10.1016/j.jconrel.2023.12.017
2090299-48-0 suppliers list
Company Name: Shanghai Changyu Medical Technology Co. Ltd.  
Tel: +86-13301875428
Website: www.chemicalbook.com/ShowSupplierProductsList30836/0_EN.htm
Company Name: Shochem(Shanghai)Co.,Ltd  
Tel: +86-021-51783479 +86-13816874662
Website: http://www.shochem.com
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Website: www.caymanchem.com
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