| Identification | Back Directory | [Name]
THYMINE-1-ACETIC ACID | [CAS]
20924-05-4 | [Synonyms]
Thymine acetic acid
1-Thyminylacetic acid
THYMINE-1-ACETIC ACID
Thymin-1-ylacetic acid
1-Carboxymethylthymine
Thymine-N1-acetic acid
ThyMine-1-acetic acid 98%
THYMINE-1-YL-ACETIC ACID
Thymin-1-ylacetic acid 98%
Thymine-1-Acetic Acid,>98%
2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetic acid
2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)
(5-METHYL-2,4-DIOXO-3H-PYRIMIDIN-1-YL)ACETIC ACID
2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1-yl)acetic acid
1(2H)-Pyrimidineacetic acid, 3,4-dihydro-5-methyl-2,4-dioxo-
[5-Methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]acetic acid
(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acid
2-[5-METHYL-2,4-DIOXO-3,4-DIHYDRO-1(2H)-PYRIMIDINYL]ACETIC ACID
2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetic acid
2-(5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)acetic acid
2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin -1-yl)acetic acid | [Molecular Formula]
C7H8N2O4 | [MDL Number]
MFCD00274250 | [MOL File]
20924-05-4.mol | [Molecular Weight]
184.15 |
| Chemical Properties | Back Directory | [Melting point ]
272-278 °C (dec.) (lit.) | [density ]
1.416 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
3.81±0.10(Predicted) | [color ]
White | [InChI]
InChI=1S/C7H8N2O4/c1-4-2-9(3-5(10)11)7(13)8-6(4)12/h2H,3H2,1H3,(H,10,11)(H,8,12,13) | [InChIKey]
TZDMCKHDYUDRMB-UHFFFAOYSA-N | [SMILES]
C1(=O)N(CC(O)=O)C=C(C)C(=O)N1 |
| Hazard Information | Back Directory | [Synthesis]
5-Methyluracil (10.0 g, 79.3 mmol) was suspended in distilled water (150 mL). Aqueous potassium hydroxide solution (50 mL, 3.6 M) was slowly added to the suspension. The mixture was stirred at room temperature for 10 minutes until the solution gradually became clear. Subsequently, chloroacetic acid (15.0 g, 159 mmol) was added to the clarified solution. The reaction mixture was heated to reflux and kept for 90 minutes. Upon completion of the reaction, the solution was cooled to room temperature and acidified with concentrated hydrochloric acid to pH=3. The acidified solution was placed in a refrigerator at 4°C overnight to promote the formation of white crystalline precipitate. The white crystalline precipitate was collected by filtration and dried under vacuum using phosphorus pentoxide (P2O5), resulting in 4.5 g of thymine-1-acetic acid in 31% yield. | [References]
[1] Chemistry - A European Journal, 2000, vol. 6, # 1, p. 62 - 72
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 2, p. 291 - 298
[3] Bioconjugate Chemistry, 2016, vol. 27, # 10, p. 2301 - 2306
[4] European Journal of Organic Chemistry, 2013, # 22, p. 4804 - 4815
[5] Patent: CN108478807, 2018, A. Location in patent: Paragraph 0022; 0053; 0070; 0071 |
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