| Identification | Back Directory | [Name]
Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester | [CAS]
2093934-94-0 | [Synonyms]
DBCO-PEG12-NHS Ester
DBCO-NH-PEG12-CH2CH2COONHS ester
Azadibenzocyclooctyne-PEG12-N-hydroxysuccinimidyl ester | [Molecular Formula]
(C2H4O)nC28H27N3O7 | [MOL File]
2093934-94-0.mol |
| Hazard Information | Back Directory | [Description]
DBCO-PEG12-NHS Ester is a monodisperse PEG linker which enable free copper click chemistry with N3 group. NHS ester moiety can react specifically and efficiently with primary amines to form a covalent amide bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. | [Uses]
DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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