| Identification | Back Directory | [Name]
DBCO-PEG6-amine,DBCO-PEG6-NH2 | [CAS]
2353409-98-8 | [Synonyms]
DBCO-PEG6-amine TFA salt
DBCO-PEG6-amine,DBCO-PEG6-NH2
Dibenz[b,f]azocine-5(6H)-butanamide, N-(20-amino-3,6,9,12,15,18-hexaoxaeicos-1-yl)-11,12-didehydro-γ-oxo- | [Molecular Formula]
C33H45N3O8 | [MDL Number]
MFCD31811530 | [MOL File]
2353409-98-8.mol | [Molecular Weight]
611.74 |
| Chemical Properties | Back Directory | [Boiling point ]
823.0±65.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Solid-Liquid Mixture | [pka]
15.14±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
DBCO-PEG6-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. | [Uses]
DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG6-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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