| Identification | Back Directory | [Name]
CH7057288 | [CAS]
2095616-82-1 | [Synonyms]
CH7057288
4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl- | [Molecular Formula]
C32H31N3O5S | [MOL File]
2095616-82-1.mol | [Molecular Weight]
569.67 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM) | [form ]
Solid | [pka]
6.89±0.40(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
CH7057288 is a potent and selective TRK inhibitor. CH7057288 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively. | [in vitro]
In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways. | [target]
| Target | Value | TrkA
(Cell-free assay) | 1.1 nM | TrkC
(Cell-free assay) | 5.1 nM | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TrkB
(Cell-free assay) 7.8 nM |
| [IC 50]
TRK | [storage]
Store at -20°C | [References]
[1] Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|