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2097509-36-7

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2097509-36-7 Structure

2097509-36-7 Structure
IdentificationBack Directory
[Name]

Thalidomide-NH-PEG2-C2-NH2 (TFA)
[CAS]

2097509-36-7
[Synonyms]

Thalidomide-NH-PEG2-NH2 TFA
Thalidomide-4-NH-PEG2-NH2 TFA
Thalidomide-PEG2-C2-NH2 (TFA)
Thalidomide-NH-PEG2-C2-NH2 (TFA)
[Molecular Formula]

C21H25F3N4O8
[MDL Number]

MFCD32690100
[MOL File]

2097509-36-7.mol
[Molecular Weight]

518.45
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Thalidomide-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
[IC 50]

Cereblon
[References]

[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919
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