2308035-51-8

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2308035-51-8 Structure

Identification	Back Directory
[Name] E3 ligase Ligand-Linker Conjugates 15
[CAS] 2308035-51-8
[Synonyms] Cereblon Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 15 4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butanoic acid Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]-
[Molecular Formula] C19H19N3O8
[MDL Number] MFCD31560483
[MOL File] 2308035-51-8.mol
[Molecular Weight] 417.37

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Hazard Information	Back Directory
[Uses] Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
[IC 50] Cereblon
[References] [1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527

Spectrum Detail	Back Directory
[Spectrum Detail] E3 ligase Ligand-Linker Conjugates 15(2308035-51-8)¹HNMR

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