| Identification | Back Directory | [Name]
VH032 thiol | [CAS]
2098836-54-3 | [Synonyms]
VHL ligand 6
VH032 THIOL (VHL LIGAND 6)
L-Prolinamide, N-acetyl-3-mercapto-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C23H30N4O4S2 | [MDL Number]
MFCD32062701 | [MOL File]
2098836-54-3.mol | [Molecular Weight]
490.64 |
| Chemical Properties | Back Directory | [Boiling point ]
805.1±65.0 °C(Predicted) | [density ]
1.304±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 50 mg/mL (101.91 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.17±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
VH032 thiol (VHL ligand 6) is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC[1]. | [IC 50]
VHL | [storage]
Store at -20°C | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
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