| Identification | Back Directory | [Name]
γ-Secretase Inhibitor XXI | [CAS]
209986-17-4 | [Synonyms]
DuPont E
γ-Secretase Inhibitor BZ
γ-Secretase Inhibitor BZ
g-Secretase Inhibitor XXI
γ-Secretase Inhibitor XXI
CoMpound E (secretase inhibitor)
BZ, γ-Secretase Inhibitor - Compound E
Compound E (γ-Secretase Inhibitor XXI)
StemSelect Compound E - CAS 209986-17-4 - Calbiochem
(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro- | [Molecular Formula]
C27H24F2N4O3 | [MOL File]
209986-17-4.mol | [Molecular Weight]
490.5 |
| Chemical Properties | Back Directory | [Boiling point ]
778.6±60.0 °C(Predicted) | [density ]
1.31 | [storage temp. ]
= -70C | [solubility ]
Soluble in DMSO | [form ]
Liquid | [pka]
12.54±0.40(Predicted) | [color ]
White to off-white | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing | [Definition]
ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene. | [Biological Activity]
Cell permeable: yes''Primary Target
γ-secretase and Notch processing Ab40 in CHO cells overexpressing wild type bAPP''Product does not compete with ATP.''Reversible: no''Target IC50: 300 pM for Aβ40 in CHO cells overexpressing wild typeβAPP; 240 pM for Aβ40370 pM for Aβ42and 320 pM for NICDrespectivelyin HEK293 cells stably transfected with βAPP695 and mNotchΔE(M1727V); 100 pM for both Aβ40 | [storage]
+4°C |
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