| Identification | Back Directory | [Name]
BETA-SECRETASE INHIBITOR IV | [CAS]
797035-11-1 | [Synonyms]
BACE-1 inhibitor
γ-Secretase Inhibitor IV
β-Secretase Inhibitor IV
β-Secretase Inhibitor IV
BETA-SECRETASE INHIBITOR IV
N-((1S,2R)-1-BENZYL-3-CYCLOPROPYLAMINO-2-HYDROXY-PROPYL)-5-(METHANESULFONYL-METHYL-AMINO)-N'-((R)-1-PHENYL-ETHYL)-ISOPHTHALAMIDE
N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-(N-methylmethylsulfonamido)-N3-((R)-1-phenylethyl)isophthalamide
3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
1,3-BENZENEDICARBOXAMIDE, N1-[(1S,2R)-3-(CYCLOPROPYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N3-[(1R)-1-PHENYLETHYL]- | [Molecular Formula]
C31H38N4O5S | [MDL Number]
MFCD09037559 | [MOL File]
797035-11-1.mol | [Molecular Weight]
578.72 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
13.72±0.46(Predicted) | [color ]
Off-white to light yellow | [InChIKey]
VPNIQGRFZCTBEZ-SPTGULJVSA-N | [SMILES]
O=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4 |
| Hazard Information | Back Directory | [Uses]
beta-Secretase Inhibitor IV is a compound that binds to the active site of BACE-1 and potently blocks its proteolytic activity. | [Biological Activity]
Cell permeable: yes''Primary Target
β-Secretase''Reversible: yes''Target IC50: 15 nM for BACE-1human and 29 nM for sAPP_NF in HEK293-APPNFEV cells |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
|