| Identification | More | [Name]
2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE | [CAS]
2103-99-3 | [Synonyms]
2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE
2-AMINO 4(P-CHLORO)PHENYL THIAZOLE
4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-AMINE
4-(4-CHLORO-PHENYL)-THIAZOL-2-YLAMINE
AKOS B000490
AKOS BBS-00000674
AURORA 13234
BUTTPARK 18\03-88
IFLAB-BB F1912-0041
OTAVA-BB BB7010240509
TIMTEC-BB SBB000503
TOSLAB 14871
4-(4-chlorophenyl)-2-thiazolamin
4-(4-chlorophenyl)-2-thiazolamine
f1654
p-chlorophenyl-4amino-2thiazole
4-(4-CHLOROPHENYL)THIAZOL-2-AMINE
4-(4-chlorophenyl)-1,3-thiazol-2-ylamine | [Molecular Formula]
C9H7ClN2S | [MDL Number]
MFCD00047058 | [Molecular Weight]
210.68 | [MOL File]
2103-99-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
169-171 °C(lit.)
| [Boiling point ]
389.8±17.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Powder | [pka]
3.95±0.10(Predicted) | [color ]
White to off-white | [λmax]
232nm(phosphate buffer sol.)(lit.) | [BRN ]
153889 | [InChI]
1S/C9H7ClN2S/c10-7-3-1-6(2-4-7)8-5-13-9(11)12-8/h1-5H,(H2,11,12) | [InChIKey]
DWGWNNCHJPKZNC-UHFFFAOYSA-N | [SMILES]
Nc1nc(cs1)-c2ccc(Cl)cc2 | [LogP]
3.411 (est) | [CAS DataBase Reference]
2103-99-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
XJ1026732
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29341000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
2-Amino-4-(4-chlorophenyl)thiazole was used in the preparation of 2-chloroacetamido-4-(4-chlorophenyl)thiazole. | [Synthesis]
GENERAL METHOD: A mixture of thiourea (1.2 mmol) and α-bromo-4-chloroacetophenone (1 mmol) in ethanol (2 mL) was stirred and reacted at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water, filtered to collect the precipitate precipitated, and dried to obtain the target product 2-amino-4-(4-chlorophenyl)thiazole. The product yields and physical properties were as follows: [6a (99% yield), white solid, melting point 150-152 °C (literature value 26: 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 26: 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 26: 180-181 °C); 6d (98% yield), white solid, melting point 203.6-204.2 °C (literature value 28/22: 204.0-204.5 °C); 6e (94% yield), bright yellow solid, melting point 287-288 °C (literature values 26,27: 285-286 °C); 6f (100% yield), white solid, melting point 172-174°C (literature values 29-31: 172°C). | [References]
[1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Chinese Chemical Letters, 2014, vol. 25, # 1, p. 172 - 175
[3] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8099 - 8109
[4] Molecules, 2017, vol. 22, # 5,
[5] Synthetic Communications, 2009, vol. 39, # 16, p. 2895 - 2906 |
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