| Identification | Back Directory | [Name]
CASPASE-1 INHIBITOR TFA SALT | [CAS]
210345-00-9 | [Synonyms]
Z-WEHD-FMK-TFA
CASPASE-1 INHIBITOR TFA SALT
Caspase-1/ICE Inhibitor Z-WEHD-FMK
Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA
Z-WE(OME)HD(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK;Z-TRP-GLU(OME)-HIS-ASP(OME)-FLUOROMETHYLKETONE
N-[(Phenylmethoxy)carbonyl]-L-tryptophyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-histidinamide methyl ester
L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester (9CI) | [Molecular Formula]
C37H42FN7O10 | [MDL Number]
MFCD07780829 | [MOL File]
210345-00-9.mol | [Molecular Weight]
763.77 |
| Chemical Properties | Back Directory | [Boiling point ]
1129.2±65.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥26.32 mg/mL in EtOH with ultrasonic; ≥46.33 mg/mL in DMSO | [form ]
Powder | [pka]
11.06±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
treatment of infected cells with pan-caspase inhibitor iv and z-wehd-fmk, an inhibitor of inflammatory caspases, elicited a near-complete blockage of c. trachomatis-induced cleavage of golgin-84. golgin-84 cleavage was blocked via treatment of infected cells with z-wehd-fmk, resulting in a lack of golgi fragmentation and a 2-log reduction in numbers of infectious bacteria.we treated infected cells with z-wehd-fmk, effectively preventing golgi fragmentation, or with dmso as a control and then labelled cells with fluorescent ceramide. confocal images revealed that ceramide was rapidly incorporated into the inclusion membrane within dmso-treated cells and accumulated inside the inclusion in bacterial membranes. in contrast, z-wehd-fmk-treated cells were only slightly fluorescent as the majority of lipid accumulated in a golgi-like structure outside the inclusion1.general caspase inhibitor (z-asp-chz-dcb) and capase-5 inhibitor (z-wehd-fmk) could not induce rrna fragmentation treated with ecyd. caspase-5 (icerei ill/ty), member of ice protease, activated pathway may be concerned with ecyd induced rrna fragmentation2. | [target]
caspase-5 | [References]
1. d. heuer, a.r. lipinski et al. chlamydia causes fragmentation of the golgi compartment to ensure reproduction. nature, 457, 2009 2. kamada, s., funahashi, y. and tsujimoto, y.(1997) cell death diff. 4, 473-478. |
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YantaiBio
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13758194781 |
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