ChemicalBook--->CAS DataBase List--->210366-15-7

210366-15-7

210366-15-7 Structure

210366-15-7 Structure
IdentificationBack Directory
[Name]

2-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-1-(phenylMethoxy)-
[CAS]

210366-15-7
[Synonyms]

6-oxo-1-phenylmethoxypyridine-2-carboxylic acid
1-(benzyloxy)-2-oxo-1,2-dihydropyridine-6-carboxylic acid
1-(Benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylic acid
1,6-dihydro-6-oxo-1-(phenylMethoxy)-2-Pyridinecarboxylic acid
2-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-1-(phenylMethoxy)-
[Molecular Formula]

C13H11NO4
[MDL Number]

MFCD20270106
[MOL File]

210366-15-7.mol
[Molecular Weight]

245.23
Chemical PropertiesBack Directory
[Melting point ]

176-177 °C
[Boiling point ]

403.3±55.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[pka]

3.98±0.20(Predicted)
[Appearance]

Off-white to light yellow Solid
Spectrum DetailBack Directory
[Spectrum Detail]

2-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-1-(phenylMethoxy)-(210366-15-7)1HNMR
Hazard InformationBack Directory
[Synthesis]

Benzyl chloride

100-44-7

1-Hydroxy-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid

94781-89-2

2-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-1-(phenylMethoxy)-

210366-15-7

General procedure for the synthesis of 1-(benzyloxy)-6-oxo-1,6-dihydropyridine-2-carboxylic acid from benzyl chloride and 1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid: 1-hydroxy-6-carboxy-2(1H)-pyridinone (15.5 g, 0.1 mol) and anhydrous potassium carbonate (27.6 g, 0.2 mol) were mixed with benzyl chloride (15.2 g, 0.12 mol) were mixed in methanol (250 mL) and reacted at reflux for 16 hours. After completion of the reaction, the mixture was filtered and the filtrate was evaporated to dryness. The residue was dissolved in water (50 mL) and acidified with 6N HCl to pH 2. A white precipitate was isolated by filtration, washed with cold water, and dried under vacuum to give 22.3 g (91% yield) of 1-benzyloxy-6-carboxy-2(1H)-pyridinone with a melting point of 176-177 °C. The product was purified by 1H NMR (1H NMR) (1H NMR) and dried under vacuum. The product was characterized by 1H NMR (300 MHz, CDCl3) and 13C NMR (75 MHz, DMSO-d6) with the following data: 1H NMR δ 5.269 (s, 2H), 6.546 (dd, J = 16 Hz, J = 6.7 Hz, 1H), 6.726 (dd, J = 16 Hz, J = 9.2 Hz, 1H), 7.39 -7.51 (m, 6H); 13C NMR δ 77.9, 106.0, 124.1, 128.5, 129.1, 129.6, 133.8, 138.7, 140.5, 157.7, 161.7. Elemental analysis (C13H11NO4) calculated values: C, 63.66 (63.75); H, 4.53 (4.55) N, 5.71 (5.52).

[References]

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4849 - 4860
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3963 - 3971
[3] Patent: WO2008/8797, 2008, A2. Location in patent: Page/Page column 58
[4] Patent: WO2007/121453, 2007, A2. Location in patent: Page/Page column 108
[5] Patent: WO2017/105565, 2017, A2. Location in patent: Paragraph 0109
210366-15-7 suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.chemicalbook.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
Tel: +8618530059196 , +8618530059196
Website: www.chemicalbook.com/manufacturer/zhengzhou-alfa-chemical-276/
Company Name: Hebei Mujin Biotechnology Co.,Ltd
Tel: +86-13288715578
Website:
Company Name: Apeloa Pharmaceutical Co., Ltd.
Tel: +86-0571-87635730 +8615858229168 , +8615858229168
Website: www.apeloa.com/en/
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207 , +8617767106207
Website: https://www.molcore.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Pure Chemistry Scientific Inc.  
Tel: 001-857-928-2050 or 1-888-588-9418
Website: www.chemreagents.com
Company Name: China Langchem Inc.  
Tel: 0086-21-58956006
Website: www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm
Company Name: Shanghai Taibao Pharmaceutical Technology Co., Ltd.  
Tel: 13816752554
Website: www.chemicalbook.com/ShowSupplierProductsList15630/0_EN.htm
Company Name: Shanghai Worldyang Chemical Co.,Ltd.  
Tel: 021-021-56795766
Website: www.worldyachem.com
Company Name: Shanghai HuanChuan Industry Co.,Ltd.  
Tel: 021-61478794
Website: www.hcshhai.com
Company Name: Taizhou GreenChem Pharmaceutical Co., Ltd.  
Tel: 0514-86654616 15366892466
Website: http://www.tzglmk.com
Company Name: Yancheng KangdiSen Pharmaceutical Co., Ltd.  
Tel: 13812573443
Website: www.chemicalbook.com/ShowSupplierProductsList19142/0_EN.htm
Company Name: Zhengzhou Huiju Chemical Co., Ltd.  
Tel: 0371-55900031 18137872243
Website: www.chemicalbook.com/supplier/11124122/
Company Name: Wuxi KaideRui Pharmaceutical Technology Co., Ltd  
Tel: 19906241957
Website: www.chemicalbook.com/ShowSupplierProductsList20128/0_EN.htm
Company Name: Hangzhou Molcore Biopharmatech Co.,Ltd  
Tel: 400-711-5280 86-571-81025280
Website: www.molcore.com
Company Name: Aikon International Limited  
Tel: 025-66113011 13155353615
Website: www.aikonchem.com
Tags:210366-15-7 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.