210688-56-5

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210688-56-5 Structure

Identification	Back Directory
[Name] 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride
[CAS] 210688-56-5
[Synonyms] PD 168568 dihydrochl PD 168568 dihydrochloride 1H-Isoindol-1-one, 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro- 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride
[Molecular Formula] C22H27N3O
[MDL Number] MFCD12828776
[MOL File] 210688-56-5.mol
[Molecular Weight] 349.47

Chemical Properties	Back Directory
[storage temp. ] Desiccate at RT
[solubility ] Soluble to 50 mM in water and to 100 mM in DMSO
[form ] Powder

[Uses]

PD 168568 is a selective D4 receptor affinity.

[in vivo]

PD 168568 (3 mg/kg, Oral) has ability to inhibit amphetamine-stimulated locomotor activity in the rat^[3].

Animal Model:	Rat^[1]
Dosage:	3 mg/kg
Administration:	Oral administration
Result:	Inhibited amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.

[IC 50]

D₄ Receptor: 8.8 nM (Ki); D₂ Receptor: 1842 nM (Ki); D₃ Receptor: 2682 nM (Ki)

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