| Identification | Back Directory | [Name]
L-Alanine, L-alanyl-L-leucyl-L-tryptophyl-L-lysyl-L-asparaginyl-L-methionyl-L-leucyl-L-lysylglycyl-L-isoleucylglycyl-L-lysyl-L-leucyl-L-alanylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucylglycyl-L-alanyl-L-valyl-L-lysyl-L-threonyl-L-leucyl-L-valylglycyl- | [CAS]
210890-55-4 | [Synonyms]
L-Alanine, L-alanyl-L-leucyl-L-tryptophyl-L-lysyl-L-asparaginyl-L-methionyl-L-leucyl-L-lysylglycyl-L-isoleucylglycyl-L-lysyl-L-leucyl-L-alanylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucylglycyl-L-alanyl-L-valyl-L-lysyl-L-threonyl-L-leucyl-L-valylglycyl- | [Molecular Formula]
C127H219N35O32S | [MOL File]
210890-55-4.mol | [Molecular Weight]
2780.38 |
| Chemical Properties | Back Directory | [Boiling point ]
2535.5±65.0 °C(Predicted) | [density ]
1.227±0.06 g/cm3(Predicted) | [Sequence]
Ala-Leu-Trp-Lys-Asn-Met-Leu-Lys-Gly-Ile-Gly-Lys-Leu-Ala-Gly-Gln-Ala-Ala-Leu-Gly-Ala-Val-Lys-Thr-Leu-Val-Gly-Ala |
| Hazard Information | Back Directory | [Uses]
Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation[1][2]. | [References]
[1] Charpentier S, et al. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics. J Biol Chem. 1998 Jun 12;273(24):14690-7. DOI:10.1074/jbc.273.24.14690
[2] van Zoggel H, et al . Antitumor and angiostatic peptides from frog skin secretions. Amino Acids. 2012 Jan;42(1):385-95. DOI:10.1007/s00726-010-0815-9 |
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