| Identification | Back Directory | [Name]
t-boc-N-amido-PEG9-azide | [CAS]
2112731-50-5 | [Synonyms]
Boc-NH-PEG9-azide
BocNH-PEG9-CH2CH2N3
t-boc-N-amido-PEG9-azide
tert-butyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate | [Molecular Formula]
C25H50N4O11 | [MDL Number]
MFCD30723242 | [MOL File]
2112731-50-5.mol | [Molecular Weight]
582.69 |
| Hazard Information | Back Directory | [Description]
t-boc-N-amido-PEG9-azide is a PEG reagent with an azide and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to free the amine. | [Uses]
Boc-NH-PEG9-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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