| Identification | Back Directory | [Name]
BETA-AMANITIN | [CAS]
21150-22-1 | [Synonyms]
b-Amanitin
β-Amanitin
B-Amanitine
beta-amatoxin
BETA-AMANITIN
beta-Amanitine
β-Amanitin
DISCONTINUED
α-Amanitin, 1-L-aspartic acid-
1-l-asparticacid-alpha-amaniti
B-amanitin from amanita phalloides
alpha-Amanitin, 1-l-aspartic acid-
β-Amanitin from Amanita phalloides
beta-Amanitin from Amanita Phalloides
8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide
,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3
Cyclo[L-Asp-L-t4Hyp-[(3R,4R)-4,5-dihydroxy-3-methyl-L-Nva-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-] | [EINECS(EC#)]
244-244-8 | [Molecular Formula]
C39H53N9O15S | [MDL Number]
MFCD00151212 | [MOL File]
21150-22-1.mol | [Molecular Weight]
919.95 |
| Chemical Properties | Back Directory | [Melting point ]
300° | [Boiling point ]
1599.6±65.0 °C(Predicted) | [density ]
1.1725 (rough estimate) | [refractive index ]
1.7400 (estimate) | [storage temp. ]
−20°C
| [solubility ]
Water: 1 mg/ml | [form ]
White to off-white powder. | [pka]
4.02±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ile-{6-hydroxy-Trp}-Gly-Ile-Gly-Cys-Asn-Pro (Sulfidebridge try4-cys8) |
| Hazard Information | Back Directory | [Mechanism of action]
β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi. It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis. The biological activity of this toxin is similar to that of α-amanitin but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions. | [Uses]
As a tool in molecular biology. | [Uses]
β-Amanitin from Amanita phalloides has been used:
- as a calibration standard for the quantification of β-Amanitin using liquid chromatography-high resolution-mass spectrometry/mass spectrometry (LC-HR-MS/MS) method.
- to determine its concentration in urine samples by capillary zone electrophoresis (CZE).
- in the analysis of β-amanitin in toxic mushrooms by liquid chromatography coupled to time-of-flight mass spectrometry.
| [General Description]
β-Amanitin belongs to the family of amatoxins. Amanitins are made of bicyclic octapeptides. β-Amanitin is composed of a carboxyl group and is acidic in nature. | [Biochem/physiol Actions]
Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis. | [IC 50]
Traditional Cytotoxic Agents |
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Sigma-Aldrich
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