| Identification | Back Directory | [Name]
gamma-amanitin | [CAS]
21150-23-2 | [Synonyms]
GAMMA-AMANITIN
α-Amanitin, 3-[(4S)-4-hydroxy-L-isoleucine]-
Cyclo[L-Asn-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-] | [Molecular Formula]
C39H54N10O13S | [MDL Number]
MFCD04000099 | [MOL File]
21150-23-2.mol | [Molecular Weight]
902.97 |
| Chemical Properties | Back Directory | [Boiling point ]
1566.5±65.0 °C(Predicted) | [density ]
1.1527 (rough estimate) | [refractive index ]
1.7400 (estimate) | [form ]
White to off-white powder. | [pka]
9.63±0.70(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
γ-Amanitin an ADC cytotoxin and isolated from themushroom. γ-Amanitin inhibitsRNA polymerase II and disrupts synthesis ofmRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells[1][2][3]. | [in vivo]
γ-amanitin (i.p.) is classified as a neutral amanitin with an LD50 in mice ranging from 0.2 to 0.5 mg/kg[3].
| [IC 50]
Traditional Cytotoxic Agents | [References]
[1] He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. DOI:10.1016/j.biologicals.2017.06.008
[2] Gong M, et al. Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3. Food Chem Toxicol. 2024 Jun;188:114665. DOI:10.1016/j.fct.2024.114665
[3] Garcia J, et al. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food Chem Toxicol. 2015 Dec;86:41-55. DOI:10.1016/j.fct.2015.09.008 |
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