| Identification | Back Directory | [Name]
PARP-2-IN-1 | [CAS]
2115698-83-2 | [Synonyms]
PARP-2-IN-1
PARP 2 IN 1,PARP2IN1
3-Pyrrolidinecarboxamide, N-[5-[(3,4-dihydro-2,4-dioxo-1(2H)-quinazolinyl)methyl]-2-fluoro-3-pyridinyl]-1-(2,2,2-trifluoroethyl)-, (3S)- | [Molecular Formula]
C21H19F4N5O3 | [MDL Number]
MFCD31813607 | [MOL File]
2115698-83-2.mol | [Molecular Weight]
465.4 |
| Hazard Information | Back Directory | [Uses]
PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM. | [IC 50]
PARP-2: 11.5 nM (IC50) | [References]
[1] Zhao H, et al. Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors. Bioorg Med Chem. 2017 Aug 1;25(15):4045-4054. DOI:10.1016/j.bmc.2017.05.052 |
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