| Identification | Back Directory | [Name]
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID | [CAS]
292870-53-2 | [Synonyms]
BV02
TOSLAB 796846
BV02 >=98% (HPLC)
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID
2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid | [Molecular Formula]
C20H15N3O5 | [MDL Number]
MFCD00356631 | [MOL File]
292870-53-2.mol | [Molecular Weight]
377.35 |
| Chemical Properties | Back Directory | [Boiling point ]
593.8±60.0 °C(Predicted) | [density ]
1.512±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >5mg/mL | [form ]
powder | [pka]
3.39±0.20(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma. | [Biochem/physiol Actions]
BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes. | [in vivo]
BV02 (10 mg/kg; i.p.; once daily; 4 days during DSS-induced colitis) enhances Akt activation in the mucosa of colitic mice, increases apoptosis, and decreases cell proliferation, further shortening the colon length[4].
BV02 (10 mg/kg; i.p.; 1 day prior to receiving PTZ) weakens the anti-epileptic effects of LV-14-3-3 and LV-HAP1 in Pentylenetetrazole (PTZ)-induced epileptic rats, increasing seizure severity, shortening latency and increasing generalized tonic clonic (GTC) values per rat[5].
BV02 (3 mg/kg; i.p.; once daily; for 3 days starting 10 days post - infection) reduces the splenic load of B. melitensis in infected mice[6].
| [IC 50]
Caspase-3 | [storage]
Store at -20°C |
|
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