| Identification | Back Directory | [Name]
CALCITONIN, HUMAN | [CAS]
21215-62-3 | [Synonyms]
calcitonin M
Unii-I0io929019
Einecs 244-276-2
human C carcinoma
CALCITONIN, HUMAN
hCT
Thyrocalcitonin
CALCITONIN M, HUMAN*
THYROCALCITONIN HUMAN
Human calcitonin (1-32)
Calcitonin, human synthetic
1,7-Dicarbacalcitonin【human】
Calcitonin Human,recombinant
Calcitonin,huMan,Calcitonin,hu
Calcitonin, human, for bioassay
calcitonin m, human c carcinoma
Calcitonin, human reduced cyclic(1→7)-disulfide
CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-NH2 (DISULFIDE BRIDGE: 1-7)
Calcitonin M, human C carcinoma, Calcitonin, human reduced cyclic (1-7)-disulfide, hCT, Thyrocalcitonin
CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2
CYST-GLY-ASN-LEU-SER-THR-CYST-MET-LEU-GLY-THR-TYR-THR-GLN-AS-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO NH2
H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2
CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 HUMAN
H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 (DISULFIDE BRIDGE: 1-7) | [EINECS(EC#)]
244-276-2 | [Molecular Formula]
C151H226N40O45S3 | [MDL Number]
MFCD00167520 | [MOL File]
21215-62-3.mol | [Molecular Weight]
3417.85 |
| Chemical Properties | Back Directory | [Boiling point ]
3061.8±65.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [RTECS ]
XP3560000 | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
powder
| [color ]
White to off-white | [biological source]
synthetic (organic) | [Water Solubility ]
Soluble to 2 mg/ml in water | [Merck ]
13,1642 | [Sequence]
Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 (Disulfide bridge:Cys1-Cys7) | [InChIKey]
LDVRMNJZLWXJPL-JKQNMTHDSA-N |
| Hazard Information | Back Directory | [Uses]
Calcitonin human has been used to study its ability to stimulate cAMP production post transfection in mammalian cell by activating human CALCRL (calcitonin receptor like receptor gene)- receptor activity-modifying protein 1 (RAMP1) and CTR (calcitonin receptor). | [Uses]
Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. A carrier peptide that can be used to internalize fusion proteins | [Uses]
Regulator (calcium). | [Brand name]
Calcimar (Rhone-
Poulenc Rorer);. | [Biochem/physiol Actions]
Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase. | [in vivo]
Calcitonin (oral gavage; 2 mg/kg; once daily; 9 w) can inhibit cartilage degradation and prevent cartilage erosion[3]. | Animal Model: | Female Sprague-Dawley rats[3] | | Dosage: | 2 mg/kg | | Administration: | Oral gavage; 2 mg/kg; once daily; 9 weeks | | Result: | Suppressed ovariectomy-induced cartilage degradation (P<0.001) compared with the carrier control.
Prevented cartilage erosion compared with treatment with the carrier alone (P<0.01), and the extent of erosions was comparable with that in sham-operated animals. |
| [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Grader reagent
|
| Telephone: |
18221735425 |
| Website: |
www.shxinping.net |
| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|