| Identification | Back Directory | [Name]
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- | [CAS]
2125450-76-0 | [Synonyms]
SAR-443122
Eclitasertib
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]-
SAR-443122,RIPK,Receptor-interacting protein kinases,SAR443122,DNL 758,DNL758,Eclitasertib,Inhibitor,DNL-758,inhibit,RIP kinase,SAR 443122 | [Molecular Formula]
C19H18N6O3 | [MOL File]
2125450-76-0.mol | [Molecular Weight]
378.38 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (330.36 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.74±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 of 0.0375 μΜ[1]. | [in vivo]
Eclitasertib (po, single dose) inhibits TNF-alpha induced hypothermia in mouse models[2]. | Animal Model: | mouse TNF-alpha induced hypothermia models[2] | | Dosage: | | | Administration: | po, single dose | | Result: | Ameliorated TNF-alpha induced hypothermia. |
| [IC 50]
RIPK1 | [storage]
Store at -20°C | [References]
[1] Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.
[2] Darwish I, et al., Rip1k inhibitors. WO2021203011 |
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