| Chemical Properties | Back Directory | [Boiling point ]
1550.7±65.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.29±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Duocarmycins | [References]
[1] Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. DOI:10.1158/1078-0432.CCR-09-2069 |
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| Company Name: |
mahaloong
|
| Tel: |
028-81192082 18180560816 |
| Website: |
https://www.mahaloong.com |
| Company Name: |
YJ Pharma
|
| Tel: |
13962794339 |
| Website: |
|
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|