2133417-13-5

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2133417-13-5 Structure

Identification	Back Directory
[Name] 1H-Pyrazole-3-carboxamide, 5-ethyl-4-methyl-N-[4-(2S)-2-morpholinylphenyl]-
[CAS] 2133417-13-5
[Synonyms] RO6889450 Ralmitaront 1H-Pyrazole-3-carboxamide, 5-ethyl-4-methyl-N-[4-(2S)-2-morpholinylphenyl]-
[Molecular Formula] C17H22N4O2
[MDL Number] MFCD34368501
[MOL File] 2133417-13-5.mol
[Molecular Weight] 314.38

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] DMSO : 100 mg/mL (318.09 mM; Need ultrasonic)
[form ] Solid
[color ] White to off-white

Hazard Information	Back Directory
[Uses] Ralmitaront (RO6889450) is an orally active agonist of trace amine-associated receptor 1 (TAAR1) with a EC50 value of 110.4 nM. Ralmitaront has antipsychotic, cognitively improvement, and antidepressant activity in rodents. Ralmitaront can be used as a neurosuppressant in the study of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder[1][2][3][4].
[IC 50] TAAR1
[References] [1] Linda S Brady, et al. Redirecting the revolution: new developments in drug development for psychiatry. Expert Opin Drug Discov. 2019 Dec;14(12):1213-1219. DOI:10.1080/17460441.2019.1666102 [2] Halff EF, et al. Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders. Trends Neurosci. 2023 Jan;46(1):60-74. DOI:10.1016/j.tins.2022.10.010 [3] ?gren R, et al. In Vitro Comparison of Ulotaront (SEP-363856) and Ralmitaront (RO6889450): Two TAAR1 Agonist Candidate Antipsychotics. Int J Neuropsychopharmacol. 2023 Sep 25;26(9):599-606. DOI:10.1093/ijnp/pyad049 [4] Yu J, et al. Elucidating the molecular pharmacology of trace amine-associated receptor 1 to advance antipsychotic drug discovery. Clin Transl Med. 2024 Feb;14(2):e1576. DOI:10.1002/ctm2.1576

Spectrum Detail	Back Directory
[Spectrum Detail] 1H-Pyrazole-3-carboxamide, 5-ethyl-4-methyl-N-[4-(2S)-2-morpholinylphenyl]-(2133417-13-5)¹HNMR

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