| Identification | Back Directory | [Name]
HSP27 inhibitor J2 | [CAS]
2133499-85-9 | [Synonyms]
J2
HSP27 inhibitor J2
4H-1-Benzopyran-4-one, 5-hydroxy-2-methyl-7-(2-thiiranylmethoxy)-
Heat shock proteins,inhibit,HSP-27 inhibitor J2,HSP27 inhibitor J2,Inhibitor,J 2,HSP,J-2 | [Molecular Formula]
C13H12O4S | [MDL Number]
MFCD32201069 | [MOL File]
2133499-85-9.mol | [Molecular Weight]
264.3 |
| Chemical Properties | Back Directory | [Boiling point ]
490.4±45.0 °C(Predicted) | [density ]
1.419±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL (94.59 mM) | [form ]
Solid | [pka]
6.37±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2]. | [References]
[1] Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900. DOI:10.1016/j.ejmech.2017.08.065
[2] Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives. |
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cjbscvictory
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13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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