| Identification | Back Directory | [Name]
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- | [CAS]
21416-87-5 | [Synonyms]
ICRF
Razoxin
Zinecard
ICRF-159
ICRF-187
Razoxane
Eucardion
ICI-59118
NSC-129943
NSC-169780
NCI-C-01627
rac-ICRF-159
PropylenediamineTetraacetylimide
2,6-Piperazinedione, 4,4'-propylenedi-
(±)-1，2-Bis(3，5-diox-opiperazinyl)propane
2,6-Piperazinedione, 4,4'-propylenedi-, (+-)-
2,6-Piperazinedione, 4,4'-propylenedi-, (.+-.)-
(+-)-(3,5,3',5'-Tetraoxo)-1,2-dipiperazinopropane
.+-.-(3,5,3',5'-Tetraoxo)-1,2-dipiperazinopropane
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-
(±)-4,4'-(1-Methyl-1,2-ethanediyl)bis(2,6-piperazinedione)
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- USP/EP/BP | [Molecular Formula]
C11H16N4O4 | [MDL Number]
MFCD01702985 | [MOL File]
21416-87-5.mol | [Molecular Weight]
268.27 |
| Chemical Properties | Back Directory | [Melting point ]
233.5°C | [Boiling point ]
411.43°C (rough estimate) | [density ]
1.2576 (rough estimate) | [refractive index ]
1.6081 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly) | [form ]
Solid | [color ]
White |
| Safety Data | Back Directory | [Safety Profile]
Suspected carcinogen
with experimental carcinogenic and
tumorigenic data. Moderately toxic by
intraperitoneal route. Experimental
teratogenic and reproductive effects. Human
systemic effects by ingestion: nausea,
thrombocytopenia, leukopenia. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx. |
| Hazard Information | Back Directory | [Chemical Properties]
White or off-white or pale beige crystals or crystalline powder, odorless, slightly bitter. Soluble in hot water, poorly soluble in water and ethanol. Melting point: 233-234°C (decomposition), melting point: 237-239°C. (+)-Dexrazoxane: [24584-09-6]. Crystallized from aqueous methanol-ether, melting point: 193°C. [α]D +11.35° (C = 5, dimethylformamide). Solubility (mg/ml): 10-12 (water), 35-43 (0.1 mol/L hydrochloric acid), 25-34 (0.1 mol/L sodium hydroxide), 6.7-10 (10% ethanol), 1 (methanol), 7.1-10 [water-dimethylformamide (1:1)], 9.7-14.5 [0.1 mol/L citrate buffer (Ph value 4)], 8.7-13 [0.1 mol/L boric acid buffer (Ph value 9)]. | [Uses]
Razoxane is an inhibitor of Topo II. | [Definition]
ChEBI: Razoxane is a N-alkylpiperazine. |
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