| Identification | Back Directory | [Name]
7-demethylsuberosin | [CAS]
21422-04-8 | [Synonyms]
7-demethylsuberosin
6-(Dimethylallyl)umbelliferone
7-hydroxy-6-(3-methylbut-2-enyl)chromen-2-one
2H-1-Benzopyran-2-one,7-hydroxy-6-(3-Methyl-2-buten-1-yl)- | [Molecular Formula]
C14H14O3 | [MDL Number]
MFCD21496371 | [MOL File]
21422-04-8.mol | [Molecular Weight]
230.26 |
| Chemical Properties | Back Directory | [Melting point ]
134-136℃ | [Boiling point ]
418.8±45.0 °C(Predicted) | [density ]
1.203±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 250 mg/ml | [form ]
A solid | [pka]
8.45±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C14H14O3/c1-9(2)3-4-10-7-11-5-6-14(16)17-13(11)8-12(10)15/h3,5-8,15H,4H2,1-2H3 | [InChIKey]
FIDUIAPDSKSUGO-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=CC(O)=C(C/C=C(/C)\C)C=C2C=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It comes from Korean Angelica sinensis and the Dai medicine Tripterygium wilfordii. | [Uses]
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound isolated from Angelica gigas Nakai, and has anti-inflammatory activity[1]. | [Definition]
ChEBI: A natural product found in Citropsis articulata. | [References]
[1] Yongfen Ma, et al. Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells. J Food Sci Nutr Vol 14, p 179～187 (2009).
[2] Yang X, et al. Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel. J Ethnopharmacol. 2023 Sep 15;313:116527.
[3] Kang SY, et al. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch Pharm Res. 2007 Nov;30(11):1368-73. DOI:10.1007/BF02977358 |
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