| Identification | Back Directory | [Name]
SHIN1 | [CAS]
2146095-85-2 | [Synonyms]
SHIN1
RZ-2994
SHIN1,RZ2994,SHIN-1,RZ 2994,Inhibitor,SHIN 1,inhibit
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)- | [Molecular Formula]
C24H24N4O2 | [MDL Number]
MFCD31657406 | [MOL File]
2146095-85-2.mol | [Molecular Weight]
400.47 |
| Chemical Properties | Back Directory | [Boiling point ]
683.6±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
11.54±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. | [storage]
Store at -20°C | [References]
[1] Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114 |
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