| Identification | Back Directory | [Name]
ent-8-iso-15(S)-Prostaglandin F2α | [CAS]
214748-66-0 | [Synonyms]
PXGPLTODNUVGFL-XNTKLVSTSA-N
ent-8-iso-15(S)-Prostaglandin F2α
ent-8-iso-15(S)-Prostaglandin F2α
ent-8-iso-15(R)-Prostaglandin F2.alpha.
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9β,11β,12α,13E,15S)-
ent-8-iso-15(S)-Prostaglandin F-2α,ent8iso15(S)Prostaglandin F2α,ent 8 iso 15(S) Prostaglandin F2α | [Molecular Formula]
C20H34O5 | [MOL File]
214748-66-0.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS (pH 7.2): >10 mg/ml |
| Hazard Information | Back Directory | [Description]
Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2α (ent-8-iso-15(S)-PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay. | [Uses]
Ent-8-Iso-15(S)-prostaglandin F2α is an isomer of 8-Isoprostaglandin F2α, with a better inhibiting activity in the whole blood platelet aggregation inhibition assay[1]. | [References]
[1] Manami S, et al. Selective Synthesis of ent-15-epi-F 2t -Isoprostane and a Deuterated Derivative, Synthesis 2007(15): 2397-2403. |
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