| Identification | Back Directory | [Name]
N3-PEG12-CH2CH2COOH | [CAS]
2152679-71-3 | [Synonyms]
Azido-PEG12-CH2CH2COOH
inhibit,AzidoPEG12acid,Inhibitor,PROTAC Linkers,Azido PEG12 acid,Azido-PEG-12-acid
N3-PEG12-CH2CH2COOH/1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oic acid | [Molecular Formula]
C27H53N3O14 | [MDL Number]
MFCD21363301 | [MOL File]
2152679-71-3.mol | [Molecular Weight]
643.721 |
| Hazard Information | Back Directory | [Uses]
Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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