| Identification | Back Directory | [Name]
Azido-PEG12-NHS ester | [CAS]
2363756-50-5 | [Synonyms]
Azido-PEG12-NHS eater
Azido PEG12 NHS ester,Azido-PEG-12-NHS ester,PROTAC Linkers,Inhibitor,AzidoPEG12NHS ester,inhibit | [Molecular Formula]
C31H56N4O16 | [MDL Number]
MFCD13184947 | [MOL File]
2363756-50-5.mol | [Molecular Weight]
740.8 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, sealed storage, away from moisture | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid-Liquid Mixture | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Azido-PEG12-NHS ester is a aqueous soluble crosslinker containing an azide group and an NHS ester. Ne azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG12-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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