| Identification | Back Directory | [Name]
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE | [CAS]
216163-53-0 | [Synonyms]
PD 174265
PD 174265 - CAS 216163-53-0 - Calbiochem
N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- | [Molecular Formula]
C17H15BrN4O | [MDL Number]
MFCD02179208 | [MOL File]
216163-53-0.mol | [Molecular Weight]
371.23 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | [form ]
Yellow solid | [color ]
Light yellow to yellow | [InChI]
1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22) | [InChIKey]
WUPUZEMRHDROEO-UHFFFAOYSA-N | [SMILES]
Brc1cc(ccc1)Nc2ncnc3c2cc(cc3)NC(=O)CC |
| Hazard Information | Back Directory | [Description]
PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity. | [Uses]
PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity. | [General Description]
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033). | [Biochem/physiol Actions]
Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity | [Enzyme inhibitor]
This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393 | [References]
[1] D W FRY. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 20: 12022-12027. DOI: 10.1073/pnas.95.20.12022 |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
nanjing
|
| Tel: |
13376084917 13376082704 |
| Website: |
www.linye-e.com/ |
|