| Identification | Back Directory | [Name]
CU-CPT-9a | [CAS]
2162962-69-6 | [Synonyms]
CPD1577
CU-CPT-9a
TLR8 inhibitor
cas 2162962-69-6
TLR8-specific antagonist 1
4-(4-hydroxy-3-methylphenyl)quinolin-7-ol
CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR
2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol
7-Quinolinol, 4-(4-hydroxy-3-methylphenyl)- | [Molecular Formula]
C16H13NO2 | [MOL File]
2162962-69-6.mol | [Molecular Weight]
251.28 |
| Chemical Properties | Back Directory | [Boiling point ]
452.6±45.0 °C(Predicted) | [density ]
1.287±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
A crystalline solid | [pka]
8.46±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).1 It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM. | [Uses]
CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. | [IC 50]
TLR8: 0.7 nM (IC50); TLR8: 21 nM (Kd) | [storage]
Store at -20°C | [References]
[1] SHUTING ZHANG. Small-molecule inhibition of TLR8 through stabilization of its resting state[J]. Nature chemical biology, 2017, 14 1: 58-64. DOI: 10.1038/nchembio.2518 |
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