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2169223-48-5

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2169223-48-5 Structure

2169223-48-5 Structure
IdentificationBack Directory
[Name]

Ethanone, 1-[4-[[3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]dec-8-yl]-2-pyrazinyl]thio]-3,3-difluoro-2,3-dihydro-1H-indol-1-yl]-
[CAS]

2169223-48-5
[Synonyms]

JAB3068
HMN23485
SHP2-IN-6
(S)-1-(4-((3-amino-5-(4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3,3-difluoroindolin-1-yl)ethan-1-one
Ethanone, 1-[4-[[3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]dec-8-yl]-2-pyrazinyl]thio]-3,3-difluoro-2,3-dihydro-1H-indol-1-yl]-
[Molecular Formula]

C22H26F2N6O2S
[MOL File]

2169223-48-5.mol
[Molecular Weight]

476.54
Chemical PropertiesBack Directory
[Boiling point ]

732.6±60.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.26±0.20(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM[1].
[References]

[1] Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1.
Spectrum DetailBack Directory
[Spectrum Detail]

Ethanone, 1-[4-[[3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]dec-8-yl]-2-pyrazinyl]thio]-3,3-difluoro-2,3-dihydro-1H-indol-1-yl]-(2169223-48-5)1HNMR
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