| Identification | Back Directory | [Name]
PZ-2891 | [CAS]
2170608-82-7 | [Synonyms]
PZ-2891
3-Pyridazinecarbonitrile, 6-[4-[2-[4-(1-methylethyl)phenyl]acetyl]-1-piperazinyl]- | [Molecular Formula]
C20H23N5O | [MDL Number]
MFCD31812779 | [MOL File]
2170608-82-7.mol | [Molecular Weight]
349.43 |
| Chemical Properties | Back Directory | [Boiling point ]
634.3±55.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:70.0(Max Conc. mg/mL);200.3(Max Conc. mM) | [form ]
Solid | [pka]
2.54±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively[1]. | [References]
[1] Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399. DOI:10.1038/s41467-018-06703-2 |
|
|