| Identification | Back Directory | [Name]
BMS-615 | [CAS]
2180127-82-4 | [Synonyms]
BMS-615
TLR7/8/9-IN-1
Inhibitor,Toll-like Receptor (TLR),inhibit,TLR7/8/9 IN 1,TLR7/8/9IN1,TLR-7/8/9-IN-1
4-[2-(3,4-Dimethoxyphenyl)-3-(1-methylethyl)-1H-indol-5-yl]-N-methyl-1-piperidineethanamine
1-Piperidineethanamine, 4-[2-(3,4-dimethoxyphenyl)-3-(1-methylethyl)-1H-indol-5-yl]-N-methyl- | [Molecular Formula]
C27H37N3O2 | [MOL File]
2180127-82-4.mol | [Molecular Weight]
435.6 |
| Chemical Properties | Back Directory | [Boiling point ]
601.4±55.0 °C(Predicted) | [density ]
1.087±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.95±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9). | [References]
[1] Mussari CP, et al. Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758. DOI:10.1021/acsmedchemlett.0c00264 |
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