| Identification | Back Directory | [Name]
Lycorine hydrochloride | [CAS]
2188-68-3 | [Synonyms]
LYCORIN
LYCORINE
NARCISSIN(P)
(-)-LYCORINE
Lycorine chloride
Licorin hydrochloride
Hydrochloric Lycorine
Lycorine hydrochloride
Licorine hydrochloride
Narcissine hydrochloride
Amarylline hydrochloride
Lycorine Hydrochloride98%
Galanthidine hydrochloride
Lycorine chloride 2188-68-3
Lycorinehydrochloride 2188-68-3
Lycorine hydrochloride USP/EP/BP
Lycorine hydrochloride, 96%(HPLC)
(1S,2S,12BS,12CS)-1,2,4,5,12B,12C-HEXAHYDRO-7H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL
1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)- | [Molecular Formula]
C16H17NO4 | [MDL Number]
MFCD00221746 | [MOL File]
2188-68-3.mol | [Molecular Weight]
287.31 |
| Chemical Properties | Back Directory | [Melting point ]
206 °C | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in water (15 mg/ml) | [form ]
powder | [color ]
White to off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month. | [InChI]
1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1 | [InChIKey]
VUVNTYCHKZBOMV-NVJKKXITSA-N | [SMILES]
Cl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Description]
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5 | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs. | [Uses]
Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli. | [Biochem/physiol Actions]
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway. | [in vivo]
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1]. | Animal Model: | 6- to 8-week-old BALB/C nude mice[1] | | Dosage: | 0 μg, 7.5 μg, 15 μg | | Administration: | Subcutaneous injection; for 14 days | | Result: | Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
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| [References]
Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168
Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483
Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407
Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174
Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
T&W GROUP
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| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
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