| Identification | Back Directory | [Name]
dihydrohonokiol | [CAS]
219565-74-9 | [Synonyms]
dihydrohonokiol
Dihydrohonokiol-B
3'-allyl-5-propyl-[1,1'-biphenyl]-2,4'-diol
2-(3-allyl-4-hydroxy-phenyl)-4-propyl-phenol
[1,1'-Biphenyl]-2,4'-diol, 3'-(2-propen-1-yl)-5-propyl- | [Molecular Formula]
C18H20O2 | [MOL File]
219565-74-9.mol | [Molecular Weight]
268.35 |
| Chemical Properties | Back Directory | [InChI]
InChI=1S/C18H20O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h4,7-12,19-20H,2-3,5-6H2,1H3 | [InChIKey]
IBKNHHZQPPUDQJ-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(O)C(CC=C)=C2)=CC(CCC)=CC=C1O |
| Hazard Information | Back Directory | [Uses]
Dihydrohonokiol B (Dihydrohonokiol) is an anxiolytic agent. Dihydrohonokiol B can reduce the neurotoxicity induced by amyloid β protein by stimulating the GABAC receptor. Dihydrohonokiol B can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1][2]. | [References]
[1] Esumi T, et al. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorg Med Chem Lett. 2004 May 17;14(10):2621-5. DOI:10.1016/j.bmcl.2004.02.067
[2] Liu B, et al. Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons. Neurosci Lett. 2005 Aug 12-19;384(1-2):44-7. DOI:10.1016/j.neulet.2005.04.081 |
|
|