| Identification | Back Directory | [Name]
Griffipavixanthone | [CAS]
219649-95-3 | [Synonyms]
Griffipavixanthone
Indeno[1,2-a]xanthen-13(8H)-one, 8a,9,10,12a-tetrahydro-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-, (8R,8aR,12aS)-(+)- | [Molecular Formula]
C36H28O12 | [MDL Number]
MFCD20260798 | [MOL File]
219649-95-3.mol | [Molecular Weight]
652.61 |
| Chemical Properties | Back Directory | [Boiling point ]
862.8±65.0 °C(Predicted) | [density ]
1.630±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6?+-.0.70(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM)[1][2][3]. | [target]
ROS | Caspase | RAF | MEK | ERK | [References]
[1] Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618. DOI:10.1080/14786419.2020.1716351
[2] Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31. DOI:10.3390/molecules19021422
[3] Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197. DOI:10.1007/s12282-018-0912-2 |
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