| Identification | Back Directory | [Name]
2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | [CAS]
2201066-35-3 | [Synonyms]
AGI-25696
2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2,3-diphenyl-6-(6-quinolinyl)- | [Molecular Formula]
C27H18N4O | [MDL Number]
MFCD31657413 | [MOL File]
2201066-35-3.mol | [Molecular Weight]
414.46 |
| Chemical Properties | Back Directory | [Boiling point ]
638.6±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.46±0.10(Predicted) | [InChI]
InChI=1S/C27H18N4O/c32-27-22(20-13-14-23-21(16-20)12-7-15-28-23)17-29-26-24(18-8-3-1-4-9-18)25(30-31(26)27)19-10-5-2-6-11-19/h1-17,29H | [InChIKey]
VJMSOWXHWUORTA-UHFFFAOYSA-N | [SMILES]
C12=C(C3=CC=CC=C3)C(C3=CC=CC=C3)=NN1C(=O)C(C1=CC=C3C(=C1)C=CC=N3)=CN2 |
| Hazard Information | Back Directory | [Uses]
AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. | [storage]
Store at -20°C | [References]
[1] Agios. Targeting MAT2A in MTAP-deleted Cancers. Presented at the American Association for Cancer Research (AACR) Annual Meeting, April 14-18, 2018, Chicago, IL, USA |
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