| Identification | Back Directory | [Name]
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[3-(hydroxymethyl)-5-(5-hydroxy-1-pentyn-1-yl)phenyl]-3-methyl-4-(1-methylethyl)- | [CAS]
2204289-53-0 | [Synonyms]
SHIN 2, SHIN-2
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[3-(hydroxymethyl)-5-(5-hydroxy-1-pentyn-1-yl)phenyl]-3-methyl-4-(1-methylethyl)- | [Molecular Formula]
C23H26N4O3 | [MOL File]
2204289-53-0.mol | [Molecular Weight]
406.48 |
| Chemical Properties | Back Directory | [Boiling point ]
725.2±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.60±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively[1]. (Rac)-SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Mootha Vamsi, et al. Method of treating and preventing viral infection comprising inhibitors of folate or one-carbon metabolism pathways such as serine hydroxymethyltransferase inhibitors: World Intellectual Property Organization, WO2022120195[P]. 2022-06-09. |
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